8 . A new USPIO contrast agent ( P 904 ) , designed for clinical application , in EAE Lewis Rat
نویسندگان
چکیده
1Dept. of Radiology, VU University Medical Center Amsterdam 2 Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht 3Dept. of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam 4Clinical Neurosciences, dept of Neuroscience and Anatomy, VU University Medical Center Amsterdam 5Dept. of Physics and Medical Technology, VU University Medical Center Amsterdam
منابع مشابه
Comparison of ultrasmall particles of iron oxide (USPIO)-enhanced T2-weighted, conventional T2-weighted, and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis.
BACKGROUND AND PURPOSE Ultrasmall particles of iron oxide (USPIO) constitute a contrast agent that accumulates in cells from the mononuclear phagocytic system. In the CNS they may accumulate in phagocytic cells such as macrophages. The goal of this study was to compare USPIO-enhanced MR images with conventional T2-weighted images and gadolinium-enhanced T1-weighted images in a model of experime...
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BACKGROUND AND PURPOSE Inflammatory multiple sclerosis (MS) lesions are characterized by microglia activation and infiltration of T cells, B cells, and macrophages across the blood-brain barrier (BBB). In the experimental autoimmune encephalomyelitis (EAE) rat model of MS, previous MR imaging investigations with a new contrast agent ultra-small-particle iron oxide (USPIO) that accumulates in ph...
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Background P-selectin, expressed on the activated platelets and endothelial cells, is one of the key adhesion molecules that regulate leukocyte trafficking in atherosclerosis. The natural and canonical ligand of selectins is a specific tetrasaccharide structure known as 6-sulfo sialyl Lewis X (SLeX). Fucoidans refer to a type of polysaccharide that contains L-fucose and sulfate ester groups, ma...
متن کاملEffect of Honey Bee Venom on Lewis Rats with Experimental Allergic Encephalomyelitis, a Model for Multiple Sclerosis
Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...
متن کاملEffect of Honey Bee Venom on Lewis Rats with Experimental Allergic Encephalomyelitis, a Model for Multiple Sclerosis
Multiple sclerosis (MS) is a progressive and autoimmune neurodegenerative disease of the central nervous system (CNS). This disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. Experimental allergic encephalomyelitis (EAE) is a widely accepted animal model for MS. EAE is created in animals by injecting the tissue of myelin basic...
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